Phytochemical and pharmacological investigations of different extracts of leaves and stem barks of Macropanax dispermus (Araliaceae): a promising ethnomedicinal plant

Abstract Background Macropanax dispermus is traditionally used to treat various diseases by ethnic people. The present research reports the pharmacological properties with phytochemical profiling of crude extracts M. leaves (MDML), its n-hexane (MDHL), carbon tetrachloride (MDTL), chloroform (MDCL), ethyl acetate (MDEL), and aqueous (MDAL) fractions, methanol stem barks (MDMS). in vitro thrombolytic activity was done on human erythrocytes whereas cytotoxic brine shrimp lethality assay. vivo analgesic examined acetic acid-induced writhing, tail immersion, formalin-induced paw licking method. In contrast, antipyretic brewer’s yeast-induced pyrexia Results MDHL MDMS showed 37.05% 42.21% significant ( p < 0.01) activity, respectively. MDCL lower LC 50 values 23.15 37.11 µg/ml during cytotoxicity test, acid writhing method, MDTL MDEL 0.001) inhibition 79.34% 80.17%, maximal possible effect (%MPE) 45.95%, 62.26%, 65.79%, 89.69% elongation time pain reaction 48.53%, 60.28%, 58.76%, 70.14% at 30, 60, 90, 120 min intervals, MDML 400 mg/kg exhibited 82.72% late phases. dose reduction rectal temperature 36.31%, 62.42%, 89.81%,, 96.82% 1, 2, 3, 4 h Conclusion current suggests that plant possess potential thrombolytic, cytotoxic, analgesic, activities.